Health and Nutrition Benefits

Bone Health

Normal bone versus osteoporosis Bone health is vitally important as we age. During the aging process bone health problems cause discomfort, pain and a host of other comorbidities. In the elderly particularly, the amount of daily intake of protein can be suboptimal and can contribute to osteoporosis, a condition where bone mineral density is low, which is associated with increasing risks of fracture. Decreased bone density and deterioration of the bone architecture lead to an increase in bone instability and vulnerability to bone fractures commonly in the wrist, spine, shoulder and hip.

Type I collagen represents 90% of organic bone mass. All bones consist of living and dead cells embedded in the extracellular matrix that make up the skeleton and are constantly remodeling or turning over building new bone. While bone is essentially brittle, it does have a significant degree of elasticity, contributed chiefly by collagen. Like other connective tissue, bone is metabolically active throughout life. As we age, the balance between bone resorption and formation is compromised, resulting in a net loss of bone tissues. Ingestion of collagen has been shown to stimulate osteoblast formation and help build new bone and restore bone density loss.

Proven Benefits for Bone Health

Research has shown that daily intake of Nippi Collagen helps to restore bone mineral density, support healthy bone metabolism and help preserve bone health. Collagen is the protein peptide that gives bone a framework for strength and flexibility and makes bones hard and strong. Nippi Collagen has numerous beneficial effects to help maintain bone health and restore bone mineral density in order to prevent the risk of osteoporosis, preserve bone health and contribute to improved quality of life as we age.

Nippi Collagen provides multiple benefits to enhance bone health by:

  • Restoring bone mineral density
  • Reducing bone resorption and stimulating bone formation
  • Increasing bone strength and decreasing the risk of fracture

Collagen is the main organic protein in bones, making up about 30% of bone composition. As we age, bone density and strength become important issues in maintaining optimal health. Stimulating osteoblasts, the cells responsible for bone formulation, to build new bone may help restore bone density loss. Nippi Collagen’s beneficial effects have been documented in multiple in vitro and in vivo trials.

Effects of Collagen Ingestion on Bone Density

In vivo animal studies conducted to investigate the effects of Nippi Collagen under a low-protein diet. Ingesting collagen peptides daily increased bone mass density and femur strength in mice. In vitro studies have also demonstrated that pro-hydroxyproline (Pro-Hyp) and hydroxyprolyl-glycine (Hyp-Gly) are observed in the blood after ingestion of collagen peptide. Research has shown that these peptide molecules induce the differentiation of cells into osteoblasts (cells responsible for bone formation) rather than osteoclasts (cells responsible for bone resorption). Pro-Hyp and Hyp-Gly act as coupling factors in the bone matrix to maintain bone mineral density and strength. Wu J et al., Assessment of effectiveness of oral administration of collagen peptide on bone metabolism in growing and mature rats. J Bone Miner Metab 22:547-553 (2004)